MEDICAMENTS FOR PREVENTING AND TREATING CIRCULATORY ORGAN DISEASES CONTAINING SPIRO-3-HETEROAZOLIDINE COMPOUNDS

• Main Authors: TOMIYA, NOBORU, SANWA KAGAKU, KENKYUSHO CO.,LTD, SAWAI, KIICHI, SANWA KAGAKU, KENKYUSHO CO., LTD, TANAKA, YUKIYA, SANWA KAGAKU, KENKYUSHO CO., LTD, NAKAMURA, SHIGEYOSHI, SANWA KAGAKU, KENKYUSHO CO, KURONO, MASAYASU, SANWA KAGAKU, KENKYUSHO CO.,LTD, MIURA, KENJI, SANWA KAGAKU, KENKYUSHO CO.,LTD, USUI, TOSHINAO, SANWA KAGAKU, KENKYUSHO CO.,LTD, SUZUKI, TUNEMASA, SANWA KAGAKU, KENKYUSHO CO.,LTD, KONDO, YASUAKI, SANWA KAGAKU, KENKYUSHO CO.,LTD, HAYASHI, MOTOHIDE, SANWA KAGAKU, KENKYUSHO CO.,LTD
• Format: Patent
• Language: English
• Published: 14.10.1992
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A medicament for preventing and treating circulatory organ diseases contains as an effective ingredient a spiro-3-heterozolidine compound represented by the following formula: wherein R and R , which may be identical or different, each represent a hydrogen atom, an alkyl group, a pyrrolizidinoalkyl group, a group -(CH2CH2O)nCH3 in which n represents an integer of 1 to 113 or a substituted or unsubstituted phenyl group or alternatively R and R may form, together with the nitrogen atom to which they are bonded, a substituted or unsubstituted heterocyclic group, optionally containing a further nitrogen or oxygen atom; T represents a sulfur atom, or a nitrogen atom which may be bonded to a hydrogen atom, U represents an oxygen or sulfur atom, or an imino group; X represents an oxygen or sulfur atom; and Y and Z, which may be identical or different, each represent a hydrogen or halogen atom or an alkyl, alkoxy or alkylmercapto group; or a pharmacologically acceptable salt or solvate thereof.