METHODS AND MATERIALS FOR EXPRESSION OF HUMAN PLASMINOGEN IN A EUKARYOTIC CELL SYSTEM

Recombinant human plasminogen may be produced in invertebrate cells or in other eukaryotic cells lacking a site-specific plasminogen activator by expression of a vector including a gene encoding human plasminogen. Human plasminogen may thus be expressed without degradation by plasmin produced by int...

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Bibliographic Details
Main Authors WHITEFLEET-SMITH, JOANN, L, MCLINDEN, JAMES, H, ROSEN, ELLIOT, D, CASTELLINO, FRANCIS, J
Format Patent
LanguageEnglish
Published 08.07.1992
Edition5
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:Recombinant human plasminogen may be produced in invertebrate cells or in other eukaryotic cells lacking a site-specific plasminogen activator by expression of a vector including a gene encoding human plasminogen. Human plasminogen may thus be expressed without degradation by plasmin produced by intracellular plasminogen activators found in mammalian cells. The plasminogen product of such expression may be purified, acylated, complexed with acylated or non-acylated fibrinolytic enzymes and formulated into pharmaceutical compositions for use in thrombolytic therapy.
Bibliography:Application Number: EP19900907737