Amine derivatives

• Main Authors: HARGREAVES, RODNEY BRIAN, MILLS, STUART DENNETT, MCLOUGHLIN, BERNARD JOSEPH
• Format: Patent
• Language: English; French; German
• Published: 15.06.1994
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention concerns novel aminopyridinium compounds of the formula I wherein R , R , R , R and R are selected from the following combinations: (a) one of R and R is a basic group selected from amino, alkylamino, dialkylamino of up to eight carbon atoms, pyrrolidino, piperidino and morpholino, or is alkyl, alkenyl, alkoxyalkyl, alkoxy, alkylthio, phenyl, phenylalkyl, cycloalkyl or cycloalkylalkyl; and the other of R and R is hydrogen, alkyl or one of the above defined basic groups; R is alkyl, alkenyl, cycloalkyl, phenyl, phenylalkyl, cycloalkylalkyl; and R and R are independently hydrogen, alkyl or alkenyl; (b) R is a basic group as defined above, R and R together form alkylene or, together with the appendant carbon atoms of the pyridine ring, complete a benzene ring; R has any of the meanings defined in (a) above; and R is hydrogen, alkyl or alkenyl; and (c) R2 has any of the meanings defined above and R is a group of the formula -NR .A- in which A together with R forms an ethylene, trimethylene or tetramethylene link and R is hydrogen or alkyl; and R and R have, independently, any of the meanings defined in (a) above; and wherein R is hydrogen, cycloalkylalkyl, alkyl, alkenyl, alkynyl or phenylalkyl; and Q is phenyl; or the group Q.N(R )- together constitutes an azaheterocyclic moietyo; Y is a physiologically acceptable anion; and any one or more of said phenyl or benzene moieties may optionally be unsubstituted or bear one or more selected substituents. The invention also includes certain closely related anhydro-base derivatives which, like the formula I componds, possess beneficial effects on the cardiovascular system. Also included are pharmaceutical compositions and processes for the manufacture of the various novel compounds.