Antigenic proteins and vaccines containing them for prevention of coccidiosis

• Main Authors: GORE, THOMAS C, PAUL, LELAND S, TEDESCO, JOHN L, MCCAMAN, MICHAEL, CHANG, RAY-JEN, ANDREWS, WILLIAM H, DRAGON, ELIZABETH B, NORDGREN, ROBERT M, FILES, JAMES G, KUHN, IRENE, NEWMAN, KAREL Z., JR, SIAS, STACEY R, BROTHERS, VIRIGINIA M, PETERSEN, GARY R
• Format: Patent
• Language: English; French; German
• Published: 03.09.1997
• Edition: 6
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; SUGARS; VINEGAR; WINE

Isolated genomic DNA molecule having a defined nucleic acid sequence and encoding an antigenic protein (I) derived from Eimeria tenella is new. (I) has a molecular wt. of about 25000 daltons and is composed of two polypeptides joined by a disulphide bond. One polypeptide has a molecular wt. of about 17000 daltons, has a blocked N-terminal amino acid and a defined amino acid sequence. The other polypeptide has a molecular wt. of about 8000 daltons and a defined amino acid sequence.