Long acting granular pharmaceutical composition

A long acting granular composition which comprises (a) a fine particulate nucleus composed of a water-insoluble substance; (b) a drug layer containing a drug which is difficult to prepare in long acting form and a non-swellable entero-soluble base; and (c) a drug-release controlling film containing...

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Main Authors KAJIYAMA, ATUSHI, FUKUI, MUENEO, MIZUMOTO, TAKAO, OHMURA, TADAYOSHI, HOSONO, TOSHIHARU
Format Patent
LanguageEnglish
French
German
Published 18.09.1991
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A long acting granular composition which comprises (a) a fine particulate nucleus composed of a water-insoluble substance; (b) a drug layer containing a drug which is difficult to prepare in long acting form and a non-swellable entero-soluble base; and (c) a drug-release controlling film containing a drug-release controlling material and an entero-soluble base. The long acting granular composition has a very satisfactory drug-release pattern and is free from the risk of abrupt disintegration in the digestive tract.
Bibliography:Application Number: EP19910302035