Thiazine (or oxazine) derivatives and preparation thereof

• Main Authors: OZEKI, MASAKATSU, YASUDA, KOUSUKE, KODATO, SHIN-ICHI, KUDO, YUKITSUKA, SUMIRE-SO 103, MAEDA, KAYOKO
• Format: Patent
• Language: English; French; German
• Published: 14.08.1991
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Thiazine (or oxazine) derivatives of the formula [I]: wherein R and R are both H or form a naphthalene ring together with the benzene ring; R and R are both H, or one of them is halogen and another is H; X is S or O; R and R are each i) H, ii) lower alkyl, iii) cycloalkyl, iv) substituted phenyl, v) naphthyl, vi) lower alkyl which is substituted by substituted or unsubstituted phenyl, or vii) S-containing heterocyclic group; one of Z and Z is O and another is H2; A is lower alkylene; R and R are each i) H, ii) lower alkyl, iii) lower alkenyl, iv) lower alkynyl, or v) lower alkyl which is substituted by substituted or unsubstituted phenyl, or both form together N-containing heterocyclic group; provided that when both of R and R are H, Z is O and either one of R and R is substituted phenyl, naphthyl or S-containing heterocyclic group, or their salts, which have calcium antagonistic activity within the cerebral tissues and are useful for prophylaxis and treatment of ischemic encephalopathia and/or cerebral neurocyte dyscrasia, and process for preparing said compounds.