Novel isoquinoline derivatives and salts thereof

The invention provides novel compounds and salts thereof, have the structure wherein R1 is a guianidinobenzoyloxy group and R2 is a hydrogen atom, a hydroxy, cyano, -COR3 (wherein R3 is an amino or lower alkyl group) or -COOR4 group [wherein R4 is a hydrogen atom, lower alkyl, phenyl, benzyl or -CH2...

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Main Authors ABE, NORIKO, ISHIGURO, SUSUMU, NAKAMUROA, HIROSHI, SEYA, MOTOHIDE, SK-MANSION NO. 3-A, NOMOTO, SHIN, OKADA MANSION NO. 1-B, SHIMADA, SHIN'ICHI, TAKESHITA, YASUYOSHI, KAWAGUCHI, NOBORU, GREEN TOWN NO. 175-1-5, KOYAMA, TADAYOSHI, SK-MANSION NO. 3-A
Format Patent
LanguageEnglish
French
German
Published 03.07.1991
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention provides novel compounds and salts thereof, have the structure wherein R1 is a guianidinobenzoyloxy group and R2 is a hydrogen atom, a hydroxy, cyano, -COR3 (wherein R3 is an amino or lower alkyl group) or -COOR4 group [wherein R4 is a hydrogen atom, lower alkyl, phenyl, benzyl or -CH2CONR5R6 group (wherein R5 and R6 are the same or different and selected from a hydrogen atom and lower alkyl groups)], and wherein R1 is a hydroxy group and wherein R2 is a -COR3 (wherein R3 is an amino or lower alkyl group) or -COOR4 group [wherein R4 is a (C1, C3 or C4) alkyl, phenyl, benzyl or -CH2CONR5R6 group (wherein R5 and R6 are the same or different and selected from a hydrogen atom and lower alkyl groups)]. The compounds, wherein R1 is a guanidinobenzoyloxy group, are useful protease inhibitors as anti-trypsin agents.
Bibliography:Application Number: EP19900125396