PENTACYCLIC TRITERPENOID COMPOUNDS AS TOPOISOMERASE INHIBITORS OR CELL DIFFERENTIATION INDUCERS

Pentacyclic triterpenoid compounds such as alpha -boswellic acid and its acetate, beta -boswellic acid and its acetate, which have an inhibitory effect on topoisomerase I and topoisomerase II, are disclosed. Compositions based on the pentacyclic triterpenoid compounds which can be used to treat vari...

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Bibliographic Details
Main Authors WANG, ZHEN-GUO CHANG BAISHAN INSTITUTE, COOK, C., EDGAR RESEARCH TRIANGLE INSTITUTE, LI, DE-HUA CHANG BAISHAN INSTITUTE OF MATERIA, LEE, YUE-WEI RESEARCH TRIANGLE INSTITUTE, FANG, QING INSTITUTE OF MATERIA MEDICA
Format Patent
LanguageEnglish
Published 15.01.1992
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:Pentacyclic triterpenoid compounds such as alpha -boswellic acid and its acetate, beta -boswellic acid and its acetate, which have an inhibitory effect on topoisomerase I and topoisomerase II, are disclosed. Compositions based on the pentacyclic triterpenoid compounds which can be used to treat various cancers in mammals are also disclosed.
Bibliography:Application Number: EP19890910793