BENZODIAZEPINES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR THERAPEUTIC USE

Benzodiazepines of formula (I) in which R9 is hydrogen or chlorine, R10 is phenyl, possibly substituted, R11 is hydrogen, R12 is oxygen or sulphur, R13 is an NH group, Ar is aromatic or heteroaromatic comprising one or more rings and in which, in particular, A is an ethylene or trimethylene bridge;...

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Main Authors PASCAL, YVES ROBERT ALAIN, JUNIEN, JEAN-LOUIS, PASCAUD, XAVIER BERNARD LOUIS, ROMAN, FRANCOIS JOSEPH, CALVET, ALAIN PIERRE
Format Patent
LanguageEnglish
French
Published 18.12.1991
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Benzodiazepines of formula (I) in which R9 is hydrogen or chlorine, R10 is phenyl, possibly substituted, R11 is hydrogen, R12 is oxygen or sulphur, R13 is an NH group, Ar is aromatic or heteroaromatic comprising one or more rings and in which, in particular, A is an ethylene or trimethylene bridge; e is 1 or 2; which are gastrin antagonists and/or central antagonists of cholecystokinin.
Bibliography:Application Number: EP19900402555