2-Oxo-1-oxa-8-azaspiro [4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof

• Main Authors: TOTH, EDIT, TOERLEY, JOZSEF, SARKADI, ADAM, SZPORNY, LASZLO, KISS, BELA, LASZY, JUDIT, LASZLOVSZKY, ISTVAN, HEGEDUES, BELA, GROO, DORA, LAPIS, ERZSEBET, PALOSI, EVA, AMBRUS ANDRAS
• Format: Patent
• Language: English; French; German
• Published: 06.04.1994
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to 2-oxo-1-oxa-8-azaspiro [4,5] decane derivatives of formula (I), wherein X represents an oxygen atom or a NR group, wherein R represents a hydrogen atom or a C1-12 alkyl or C3-6cycloalkyl group, or a carbocyclic C6-10aryl or carbocylic C6-10aryl-C1-4alkyl group optionally substituted on the aromatic ring by one or more halogen atoms, C1-4 alkyl or C1-4alkoxy groups; R and R together represent a methylene group or when X is a >NR group, one of R and R may additionally represent a hydroxyl group and the other represent a methyl group; Z represents a hydrogen or halogen atom or a trihalomethyl or a C2-4alkanoyl group; and n is 2 or 3; and all optical isomers and mixtures thereof and all acid addition and quarternary ammonium salts thereof. The invention further relates to pharmaceutical compositions containing these compounds and processes for their preparation. The compounds of formula (I) possess psychotropic and antiallergic properties and a low toxicity. Thus, they may be useful for the treatment of psychiatric and allergic diseases.