Process to prepare coated particles

A method of producing a fine coated pharmaceutical preparation comprises cooling fine liquid droplets composed of a liquid medium, a drug dissolved or suspended in the liquid medium, and as required, a binder, to a temperature not higher than the freezing point of the liquid medium to form frozen pa...

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Bibliographic Details
Main Authors SHIMANO, KIMIHIDE, KOYAMA, IKUO, OZAWA, YASUO
Format Patent
LanguageEnglish
French
German
Published 27.02.1991
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A method of producing a fine coated pharmaceutical preparation comprises cooling fine liquid droplets composed of a liquid medium, a drug dissolved or suspended in the liquid medium, and as required, a binder, to a temperature not higher than the freezing point of the liquid medium to form frozen particles aof the drug and, as required, the binder; adjusting the particle sizes of the fine frozen particles; mixing the fine frozen particles with a fine powder of a coating material having a particle diameter less than said particles at a temperature above the freezing point of the liquid medium to cause the fine powder of the coating material to adhere to the surface of said particles; and then removing the liquid medium from the resulting coated particles.
Bibliography:Application Number: EP19890308793