Tri-aza macrocycles and processes for their production

Tri-aza macrocycles of formula (1): wherein m and n, which may be the same of different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R , R and R , which may be the same of different, is each a hydrogen atom or a group -CO2H or...

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Bibliographic Details
Main Authors PARKER, DAVID, EATON, MICHAEL ANTHONY WILLIAM
Format Patent
LanguageEnglish
French
German
Published 13.11.1996
Edition6
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Tri-aza macrocycles of formula (1): wherein m and n, which may be the same of different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R , R and R , which may be the same of different, is each a hydrogen atom or a group -CO2H or -P(O)(XH)R (where R is an oxygen or sulphur atom and R is a hydrogen atom or an alkyl or alkoxy group), with the proviso that at least one of R , R and R is a -P(O)(XH)R group; L is a covalent bond or a linker group; Z is a hydrogen atom or a reactive functional group; and metal complexes and/or salts thereof; are described together with processes for their preparation and compositions containing them. The compounds are useful as imaging agents, and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and may be coupled to other molecules, such as proteins, for use in diagnosis and therapy.
Bibliography:Application Number: EP19900306942