Monoclonal antibodies to preS2 and preS1 polypeptides of the hepatitis B viral envelope

• Main Authors: FLOREANI, MARCO F, MIMMS, LARRY T, ROSENLOF, ROBERT V, TYNER, JOAN D, WITTERS, ERIC, EBLE, KIM S
• Format: Patent
• Language: English; French; German
• Published: 03.10.1990
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

Murine monoclonal antibodies are provided which bind specifically to the PreS1 and PreS2 polypeptides of the hepatitis B virus surface antigen (HBsAg) complex and which are useful to assay for PreS1 or PreS2 in samples of physiological material. The antibodies can also be used to subtype HBV, to raise the immunogenicity of blood plasma against HBV, to measure anti-PreS1 and anti-PreS2 antibodies, and to identify and characterize antigenic epitopes of PreS1 and PreS2 which may be useful in HBV subunit vaccines.