Solid pharmaceutical preparations and process for their manufacture

The present invention relates to a process for the preparation of regulated release solid pharmaceutical compositions comprising 4-(2'-nitro-phenyl)-2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydro-pyr idine (referred to further on as "nifedipine") as active ingredient which comprises a...

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Main Authors TORMA, ZOLTAN, KRISZTIAN, MARIA, TOEMPE, PETER, ERDOS, SANDOR, HEGEDUES, ARANKA NEE SZIMA, CSOERGO, MARGIT, KENDERFI, JOZSEF, GOERGENYI, FRIGYES, BARCZAY, ERZSEBET, FEKETE, MARTON, MANDI, ATTILA, TAJTHY, EVA, NEE JUHASZ
Format Patent
LanguageEnglish
French
German
Published 06.11.1996
Edition6
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a process for the preparation of regulated release solid pharmaceutical compositions comprising 4-(2'-nitro-phenyl)-2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydro-pyr idine (referred to further on as "nifedipine") as active ingredient which comprises admixing a solution or solutions of 1 part by weight of nifedipine, 0.1-1.5 parts by weight of one or more hydrophilizing agent(s) and 0.05-1.5 parts by weight of one or more retarding agent(s) formed with one or more identical or different solvent(s) completely or partly and applying the solution(s) thus obtained simultaneously or in succession onto an inert carrier, drying and sieving the product thus obtained and subsequently admixing the same with suitable conventional auxiliary agents and compressing the mixture thus obtained to tablets in a known manner and coating the tablets or filling the mixture into capsules.
Bibliography:Application Number: EP19900104718