Process for the preparation of clavulinic acid and pharmaceutically acceptable salts from fermentation broths of Streptomyces sp

• Main Authors: DE URRIES SENANTE, PILAR J, GARCIA ALVAREZ, CONCEPCION, FLORIANO MARTIN, PABLO
• Format: Patent
• Language: English; French; German
• Published: 25.09.2002
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HETEROCYCLIC COMPOUNDS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; SPIRITS; VINEGAR; WINE

It comprises : (a) flocculation of the culture broth using an inorganic electrolyte as a coagulation agent along with an organic polyelectrolyte as a flocculation coadjuvant; (b) purification of the cited acid contained in the culture broth, once flocculated and decanted, by formation, as stable int...