Process for the preparation of clavulinic acid and pharmaceutically acceptable salts from fermentation broths of Streptomyces sp

It comprises : (a) flocculation of the culture broth using an inorganic electrolyte as a coagulation agent along with an organic polyelectrolyte as a flocculation coadjuvant; (b) purification of the cited acid contained in the culture broth, once flocculated and decanted, by formation, as stable int...

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Bibliographic Details
Main Authors DE URRIES SENANTE, PILAR J, GARCIA ALVAREZ, CONCEPCION, FLORIANO MARTIN, PABLO
Format Patent
LanguageEnglish
French
German
Published 25.09.2002
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
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Summary:It comprises : (a) flocculation of the culture broth using an inorganic electrolyte as a coagulation agent along with an organic polyelectrolyte as a flocculation coadjuvant; (b) purification of the cited acid contained in the culture broth, once flocculated and decanted, by formation, as stable intermediate products, of salts derived from primary, secondary and tertiary amines; (c) formation of pharmaceutically acceptable salts of the active principle. The cited new process is useful due to its inhibitory activity of beta -lactamases and its marked synergic effect when it is associated with other beta -lactamic antibiotics of the type of penicillin and cephalosporins.
Bibliography:Application Number: EP19900500023