USE OF ACETOGENINS IN THERAPY AS ANTIPARASITIC SUBSTANCES

• Main Authors: CAVE, ANDRE, HOCQUEMILLER, REYNALD, LAPREVOTE, OLIVIER
• Format: Patent
• Language: English; French
• Published: 08.07.1992
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a new use as an antiparasitic means of a substance chosen from the group comprising tetrahydrofuranyllactones whose formula contains (a) an optionally substituted -lactone end group, (b) a divalent alkylene group with a C9-C20 linear hydrocarbon chain containing 1 to 6 secondary OH groups which are, if appropriate, protected in the ether or ester form, on the other hand, or converted into oxo form, on the other hand, the said alkylene group being linked by one of its valencies to the said -lactone group, (c) at least one optionally substituted divalent tetrahydrofuranyl group, the said tetrahydrofuranyl group being linked in position 2 of its ring to the said alkylene group, and (d) a monovalent alkyl group with a C7-C17 linear hydrocarbon chain capable of containing up to 6 secondary OH groups which are, if appropriate, protected in the ether or ester form, on the one hand, or converted into oxo form on the other hand, the said linear alkyl group being linked by its valency to the said tetrahydrofuranyl group in position 5 of the ring of the said tetrahydrofuranyl group, the total number of OH groups which are, if appropriate, protected or converted into oxo group, being lower than or equal to 8.