NEW SILYLATING AGENT FOR THE PREPARATION OF CHROMATOGRAPHIC SUPPORTS

• Main Authors: CARDINALI, FRANCO, LONGOBARDI, MARIA GRAZIA, ZIGGIOTTI, ALESSANDRA, VISCOMI, GIUSEPPE CLAUDIO
• Format: Patent
• Language: English
• Published: 16.01.1991
• Edition: 5
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; TESTING; THEIR RELEVANT APPARATUS; TRANSPORTING

A new mono-silylating agent of general formula (I) (R1,R2,R3)Si-NH-CO-O-Si(R1,R2,R3) (I) is described as well as its use in the preparation of chromatographic supports based on silica with functional groups covalently bonded thereto, the so-called "bonded stationary phases". The new compounds are easy and safe to prepare from the corresponding mono-halosilanes with ammonium carbamate, and their use as silylating agents leads to stationary phases with a higher degree of surface coating than that attainable with the corresponding chlorosilanes.