NEW SILYLATING AGENT FOR THE PREPARATION OF CHROMATOGRAPHIC SUPPORTS

A new mono-silylating agent of general formula (I) (R1,R2,R3)Si-NH-CO-O-Si(R1,R2,R3) (I) is described as well as its use in the preparation of chromatographic supports based on silica with functional groups covalently bonded thereto, the so-called "bonded stationary phases". The new compou...

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Bibliographic Details
Main Authors CARDINALI, FRANCO, LONGOBARDI, MARIA GRAZIA, ZIGGIOTTI, ALESSANDRA, VISCOMI, GIUSEPPE CLAUDIO
Format Patent
LanguageEnglish
Published 16.01.1991
Edition5
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PHYSICS
TESTING
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:A new mono-silylating agent of general formula (I) (R1,R2,R3)Si-NH-CO-O-Si(R1,R2,R3) (I) is described as well as its use in the preparation of chromatographic supports based on silica with functional groups covalently bonded thereto, the so-called "bonded stationary phases". The new compounds are easy and safe to prepare from the corresponding mono-halosilanes with ammonium carbamate, and their use as silylating agents leads to stationary phases with a higher degree of surface coating than that attainable with the corresponding chlorosilanes.
Bibliography:Application Number: EP19890202171