DIBENZOFURANCARBOXAMIDES, THEIR USE AS PHARMACEUTICAL AGENTS, A COMPOSITION CONTAINING THE SAME, AND A PROCESS FOR THE PREPARATION THEREOF

This invention provides certain dibenzofurancarboxamides as defined by the formula: where R1 is hydrogen, amino, alkylamino or halo; R2 is hydrogen, halo, sulfamyl, alkylsulfamyl or alkylsulfonyl; R min is hydrogen or alkyl or together with a vicinal R min group may form a double bond; and R is cert...

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Main Authors YOUSSEFYEH, RAYMOND D, AIREY, JOHN EDWARD, KLEIN, SCOTT IRA, POWERS, MATTHEW RAY, CAMPBELL, HENRY F, KUHLA, DONALD E
Format Patent
LanguageEnglish
Published 15.05.1991
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention provides certain dibenzofurancarboxamides as defined by the formula: where R1 is hydrogen, amino, alkylamino or halo; R2 is hydrogen, halo, sulfamyl, alkylsulfamyl or alkylsulfonyl; R min is hydrogen or alkyl or together with a vicinal R min group may form a double bond; and R is certain specific nitrogen heterocyclic groups. The compounds of the invention are useful as 5HT3 antagonists having unique CNS, anti-emetic and gastric prokinetic activity void of any significant D2 receptor binding properties. The invention also provides processes necessary for the preparation of the compounds of the invention.
Bibliography:Application Number: EP19890304131