HUMAN MONOCLONAL ANTIBODY AND DRUG FOR PROPHYLAXIS AND TREATMENT OF INFECTIOUS DISEASES COMPRISING SAME AS EFFECTIVE INGREDIENT

• Main Authors: FUKUDA, TAMOTSU, ONO, YASUSHI, SHIGETA, SHIRO, KUROIWA, YASUYUKI, OOKA, HISAYOSHI
• Format: Patent
• Language: English; French; German
• Published: 16.03.1989
• Edition: 4
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

A human monoclonal antibody which reacts with several O antigens of Pseudomonas aeruginosa (esp. with O antigens of type A+F, D+I, E+F, or G+H) is obtd. by culture of a suitable antibody-producing cell line which may be either a virus-transformed cell line (e.g. Epstein-Barr virus-transformed) or a hybridoma derived from human or animal cells, and esp. from normal lymph cells. The antibody is obtd. by culture of one of the following cell lines: MP-5082 (FERM P9745); MP-4095 (FERM-P 9750); MP-5064 (FERM-P 9751); MP-5075 (FERM-P 9752); MP-5104 (FERM-P 9753); MP -5038 (FERM-BP 1596); MP-5035 (FERM-BP 1598) or MP-5046 (FERM -BP 1599).