1-ARYL-3-QUINOLINE- AND 1-ARYL-3-ISOQUINOLINE-CARBOXAMIDES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

This invention relates to 1-aryl-3-quinolinecarboxamides and 1-aryl-3-isoquinolinecarboxamides of the formula I wherein WXYZR is the bivalent radical N-CH=C-C=O, N-CH2-CH-C=O, N-CH2-C=C-OH, C=N-CH-C=O, or C=N-C=C-OH; R and R are independently halogen, loweralkyl or loweralkoxy; R is substituted or u...

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Bibliographic Details
Main Authors HAMER, RUSSELL RICHARD LEE, GLAMKOWSKI, EDWARD J
Format Patent
LanguageEnglish
Published 07.11.1990
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to 1-aryl-3-quinolinecarboxamides and 1-aryl-3-isoquinolinecarboxamides of the formula I wherein WXYZR is the bivalent radical N-CH=C-C=O, N-CH2-CH-C=O, N-CH2-C=C-OH, C=N-CH-C=O, or C=N-C=C-OH; R and R are independently halogen, loweralkyl or loweralkoxy; R is substituted or unsubstituted phenyl, pyridyl, pyrimidyl, pyrazinyl, triazinyl, thiazolyl, thiadiazolyl, isoxazolyl, oxadiazolyl, quinolyl, isoquinolyl, or benzothiazolyl; and m and n are integers independently having values of zero or 1; the optical antipodes and pharmaceutically acceptable acid addition salts thereof, and to a process for their preparation. The 1-aryl-3-quinolinecarboxamides and 1-aryl-3-isoquinolinecarboxamides of the present invention are useful as antiinflammatory and analgetic agents.
Bibliography:Application Number: EP19880119541