PYRIDINE OR PYRIDAZINE DERIVATIVES AS CARDIO-PROTECTIVE AGENTS AND FOR THE TREATMENT OF ISCHEMIC DISEASE, AND PROCESS FOR THEIR PREPARATION

A pharmaceutical composition as a cardioprotective agent or as a therapeutic agent for ischemic disease comprising a compound of the formula: wherein R is lower alkyl substituted with a heterocyclic group; carbamoyl substituted with heterocyclic(lower)alkyl or with lower alkylamino(lower)alkyl; N-co...

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Main Authors TAKAYA, TAKAO 5-87, SUIMEIDAI 1OME, TAKASUGI, HISASHI 14-33, HAMAGUCHINISHI 1OME, ESUMI, KIMIO 5-11-305, SUMIYOSHIYAMATE 1OME, SAKAI, HIROYOSHI, SAKAMOTO, YOSHIE, KUNO, ATSUSHI 24-6, SHINKOFUDAI 5OME, MAEDA, KAZUHIRO
Format Patent
LanguageEnglish
Published 21.07.1993
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A pharmaceutical composition as a cardioprotective agent or as a therapeutic agent for ischemic disease comprising a compound of the formula: wherein R is lower alkyl substituted with a heterocyclic group; carbamoyl substituted with heterocyclic(lower)alkyl or with lower alkylamino(lower)alkyl; N-containing heterocycliccarbonyl optionally substituted with lower alkyl; or ureido substituted with lower alkylamino(lower)alkyl; and R is phenyl substituted with nitro, and X is =N- or = @@, in which R is lower alkyl; or R is lower alkyl, and X is = @@, in which R is phenyl substituted with nitro; or its salt, as an active ingredient, in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient, and a process for the preparation of some of said compound or their salts
Bibliography:Application Number: EP19880309155