Method for detecting and confirming the presence of antibodies

A non-competitive method for detecting the presence of Hepatitis B core antibody (anti-HBc) in a biological fluid is provided. The method comprises contacting the fluid with an insoluble surface coated with hepatitis B core antigen (HBcAg). The surface is then contacted with a mixture of a labeled a...

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Bibliographic Details
Main Authors SITO, ALEXANDER F, GELTOSKY, JOHN E, NELLES, MITCHELL J
Format Patent
LanguageEnglish
French
German
Published 22.02.1989
Subjects
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Summary:A non-competitive method for detecting the presence of Hepatitis B core antibody (anti-HBc) in a biological fluid is provided. The method comprises contacting the fluid with an insoluble surface coated with hepatitis B core antigen (HBcAg). The surface is then contacted with a mixture of a labeled antibody specific for human IgG and a labeled antibody specific for human IgM. Detection of the label bound to the insoluble surface indicates the presence of anti-HBc in the sample. A method for confirming the presence of an antibody of interest in a biological fluid is also provided.
Bibliography:Application Number: EP19880307476