Process for the preparation of cell wall components from Halobacteria, and their use as medicaments

• Main Authors: SPERZEL, MICHAEL, FLESCH, INGE, HILDEBRAND, HEINZ, PIEL, NORBERT, BAUMGARTEN, JORG, BRUNNER, HELMUT, DR
• Format: Patent
• Language: English; French; German
• Published: 19.10.1988
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Die Erfindung betrifft ein Verfahren zur Herstellung von Zellwandkomponenten aus Kulturen von Archaebakterien, das dadurch gekennzeichnet ist, daß man Archaebakterien anzüchtet, das Zellwandprotein der Archaebakterien isoliert, das Zellwandprotein enzymatisch abbaut und die Abbauprodukte reinigt und isoliert, wobei die Auswahl der Fraktionen bei den einzelnen Reinigungsschritten ausschließlich aufgrund der biologischen Aktivität der Fraktionen erfolgt. Außerdem betrifft die Erfindung Arzneimittel, die solche Zellwandkomponenten enthalten. The process is characterised in that Archae bacteria are cultured, the cell wall protein of the Archae bacteria is isolated, the cell wall protein is enzymatically degraded and the degradation products are purified and isolated, the choice of the fractions in the individual purification steps being carried out exclusively on the basis of the biological activity of the fractions. Medicaments which contain such cell wall components are additionally described.