1,2,4-Triazinone derivatives, their preparation and use

Compounds of formula (I): (I) (in which: R1 is hydrogen or alkl; R2 is a variety of groups or atoms; R3 is optionally substituted hydroxy or -(NH)n-NR5R6, wherein R5 and R6 are a variety of groups or atoms, preferably alkyl substituted by heterocyclic, and n is 0 or 1; Q is oxygen or sulfur; and A i...

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Main Authors SHIMOJI,YASUO, KATAOKA,MITSURU, KOIKE,HIROYUKI, OSHIMA,TAKESHI, MORISAWA,YASUHIRO, NAGAHORI,HITOSHI, SUGIYAMA,MITSUO, SAITO,FUJIO
Format Patent
LanguageEnglish
French
German
Published 23.09.1987
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Compounds of formula (I): (I) (in which: R1 is hydrogen or alkl; R2 is a variety of groups or atoms; R3 is optionally substituted hydroxy or -(NH)n-NR5R6, wherein R5 and R6 are a variety of groups or atoms, preferably alkyl substituted by heterocyclic, and n is 0 or 1; Q is oxygen or sulfur; and A is a C1-C6 alkylene group) have valuable cardiotionic activity and may be used for the treatment of cardiac disorders. They may be prepared from corresponding compounds containing a benzene ring with a group -QH at the 1-position and a group -CO-CHR1-NH-COOR7 at the 4-position by ring closure and introduction of the group of formula -A-CO-R3 in any order.
Bibliography:Application Number: EP19870302443