TRANSMISSIBLE, MAMMALIAN GENES ASSOCIATED WITH TUMOR METASTASIS

• Main Authors: WEINBERG, ROBERT, A, BERNSTEIN, SHELLY, C
• Format: Patent
• Language: English; French; German
• Published: 10.12.1986
• Edition: 4
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SUGARS; TESTING; VINEGAR; WINE

Un procédé permet de détecter un gène isolé et transmissible d'un mammifère, associé à la métastase de tumeurs. On a détecté et identifié par ce procédé un gène associé à la métastase et originaire de la lignée ME-180 du cancer cervical humain, provoquant des métastases de l'épiploon de même qu'un gène associé à la métastase et originaire de la lignée SK-N-MC des cellules humaines de neuroblastomes, provoquant des métastases de la zone sus-orbitaire. A method for detecting a discrete, transmissible, mammalian gene associated with tumor metastasis. Using the method, a gene associated with metastasis and originating in the human cervical carcinoma line ME-180, metastatic to omentum, and a gene associated with metastasis and originating in the human neuroblastoma cell line SK-N-MC, metastatic to the supraorbital area, have been detected and identified.