PROSTACYCLIN DERIVATIVES

• Main Authors: GALAMBOS, GEZA, KANAY, KAROLY, HADHAZY, PAL, VIRAG, SANDOR, IVANICS, JOZSEF, TOMOSKOZY, ISTVAN, STADLER, ISTVAN, KORMOCZI, PETER, DORMAN, GYORGY, KOVACS, GABOR, KISS, MIKLOS
• Format: Patent
• Language: English
• Published: 13.05.1987
• Edition: 4
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

    The invention relates to novel interfuranylene-prosta-cyclin derivatives of the general formula (I) wherein R stands for hydrogen or a straight or branched chain C16 alkyl group, an inorganic cation or for the protonated form of a base containing an amino group; R stands for hydrogen, a C1-4 alkanoyl or benzoyl group, a monosubstituted benzoyl, trialkylsilyl or an alkoxy-alkyl group; R stands for a straight or branched chain C1-6 alkyl group, a phenyl group optionally substituted by halogen or by a C1-4 alkyl group, a heteroaryl group optionally substituted by halogen or by a C1-4 alkyl group or a cycloalkyl group; A stands for an ethylene or for a cis- or trans-vinylene or -C IDENTICAL C- group; B means a chemical bond, a -CHR -, -CHR -CH2- or a -CH2-O- group: and R means hydrogen or a C1-4 alkyl group. The compounds of the formula (I) can be used therapeutically as platelet aggregation inhibiting, anti-thrombotic, hypotensive and anti-antherosclerotic agents; they are much more stable than the natural prostacyclin derivatives.