PYRIDONE ESTERS AS INOTROPIC AGENTS
Described are compounds of the formula wherein R is hydrogen, lower alkyl, halo, cyano, hydroxy, amino, lower alkylamino, -CH2NH2, -CH2OH or -COOR''; R' is hydrogen, lower cycloalkyl or lower alkenyl, lower alkynyl, lower cycloalkyl, -(W)nY wherein W is straight or branched chain lowe...
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Main Authors | , , |
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Format | Patent |
Language | English French German |
Published |
09.07.1987
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Edition | 4 |
Subjects | |
Online Access | Get full text |
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Summary: | Described are compounds of the formula wherein R is hydrogen, lower alkyl, halo, cyano, hydroxy, amino, lower alkylamino, -CH2NH2, -CH2OH or -COOR''; R' is hydrogen, lower cycloalkyl or lower alkenyl, lower alkynyl, lower cycloalkyl, -(W)nY wherein W is straight or branched chain lower alkyl or lower alkenyl, n is 0 to 5, and Y is Ar, lower cycloalkyl, lower alkenyl, lower alkynyl, -COOZ wherein Z is lower alkyl, or NAB wherein A and B are, independently, lower alkyl, benzyl or substituted benzyl, and Ar is 2, 3 or 4-pyridyl, pyridazinyl, pyrimidinyl, quinolyl, isoquinolyl, phthalazinyl, quinazolinyl, thiazolyl, phenyl, benzyl, furyl, tetrahydrofuryl or thienyl, unsubstituted or substituted with lower alkyl, lower alkoxy, halo, amino, or -CF3; R''' is -COOR'', and X is oxygen or nitrogen; or a pharmaceutically acceptable salt thereof, and their use in the treatment of impaired ventricular myocardial contractility. The compounds exhibit cardiotonic activity. |
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Bibliography: | Application Number: EP19850903959 |