NAPHTHYL OR TETRAHYDRONAPHTHYL-SUBSTITUTED NAPHTHOIC ACID AND DE RIVATES

Compounds of the formulas: +TR where X is methyl, methoxy, chlorine, or hydrogen, Y and Y1 are fluorine or hydrogen, R is hydroxy, alkoxy with 0 or 1 hydroxy substituent, aroxy, or NR1R2 where R1 is hydrogen, alkyl with 0 or 1 hydroxy substituent or aryl and R2 is alkyl with 0 or 1 hydroxy substitue...

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Bibliographic Details
Main Authors HOBBS, PETER, DUNCAN, DAWSON, MARCIA, ILTON, DERDZINSKI, KRZYSZTOF, ANDRZEJ
Format Patent
LanguageEnglish
French
German
Published 12.08.1985
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Compounds of the formulas: +TR where X is methyl, methoxy, chlorine, or hydrogen, Y and Y1 are fluorine or hydrogen, R is hydroxy, alkoxy with 0 or 1 hydroxy substituent, aroxy, or NR1R2 where R1 is hydrogen, alkyl with 0 or 1 hydroxy substituent or aryl and R2 is alkyl with 0 or 1 hydroxy substituent or aryl with the proviso that when Y or Y1 is fluorine, the other Y or Y1 is hydrogen. These compounds are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.
Bibliography:Application Number: EP19840900792