PROCESS FOR THE PREPARATION OF ANTHRACYCLINONES

The present invention relates to a new process for the preparation of anthracyclinones of the formula I in which R denotes C1-C4-alkyl, R1 denotes H or OH, and R2 and R3 are different and each represent H or OH, and R4 and R5 are different and each represent H or OH, starting from a compound of the...

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Bibliographic Details
Main Authors KROHN, KARSTEN, DR, BEHNKE, BERT
Format Patent
LanguageEnglish
German
Published 15.06.1988
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a new process for the preparation of anthracyclinones of the formula I in which R denotes C1-C4-alkyl, R1 denotes H or OH, and R2 and R3 are different and each represent H or OH, and R4 and R5 are different and each represent H or OH, starting from a compound of the formula II in which R1 and R have the abovementioned meaning. The compounds of the formula I are valuable intermediates in the preparation of the corresponding glycosides having cytostatic efficacy.
Bibliography:Application Number: EP19840109378