PROCESS FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS

The invention relates to a process for the preparation of compounds of the formula I (I) in which n is 1 or 2, R represents hydrogen, an aliphatic, cycloaliphatic, aromatic, araliphatic, cycloaliphatic-aliphatic radical or a radical ORa or SR2, in which Ra denotes alkyl, aryl or heteroaryl, R1 denot...

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Bibliographic Details
Main Authors URBACH, HANSJORG, HENNING, RAINER
Format Patent
LanguageEnglish
German
Published 05.08.1987
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a process for the preparation of compounds of the formula I (I) in which n is 1 or 2, R represents hydrogen, an aliphatic, cycloaliphatic, aromatic, araliphatic, cycloaliphatic-aliphatic radical or a radical ORa or SR2, in which Ra denotes alkyl, aryl or heteroaryl, R1 denotes hydrogen, an aliphatic, cycloaliphatic-aliphatic, aromatic, araliphatic, heteroaromatic radical or an aminoacid side chain, R2 and R3 are identical or different and denote hydrogen, an aliphatic, cycloaliphatic, aromatic or araliphatic radical, and R4+R5, together with the atoms carrying them, form a heterocyclic ring system, which comprises reacting trifluoromethanesulfonic acid derivatives of the formulae II or III with aminoacid esters of the formulae IV or V respectively. The invention also relates to compounds of the formula III and a process for their preparation.
Bibliography:Application Number: EP19840104690