Plasmids and modified strains of Vibrio cholerae, their preparation and derived vaccines
Plasmids and modified strains of Vibrio cholerae are prepared which are a genetically stable nontoxinogenic form of Vibrio cholerae which has a deletion mutation in both copies of the A1-peptide-encoding gene, resulting in the loss of a gene sequence required for expression of a toxic A1 peptide. Th...
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Main Author | |
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Format | Patent |
Language | English French German |
Published |
14.11.1984
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Subjects | |
Online Access | Get full text |
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Summary: | Plasmids and modified strains of Vibrio cholerae are prepared which are a genetically stable nontoxinogenic form of Vibrio cholerae which has a deletion mutation in both copies of the A1-peptide-encoding gene, resulting in the loss of a gene sequence required for expression of a toxic A1 peptide. The modified strains are useful as live or dead oral vaccines. |
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Bibliography: | Application Number: EP19840870058 |