Derivatives of pyridinium thiomethyl cephalosporins, process for their preparation and pharmaceutical compositions containing them

• Main Authors: SALHI, ALI, LABEEUW, BERNARD
• Format: Patent
• Language: English; French; German
• Published: 21.09.1983
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METALLURGY OF IRON; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSING OF PIG-IRON, e.g. REFINING, MANUFACTURE OFWROUGHT-IRON OR STEEL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TREATMENT IN MOLTEN STATE OF FERROUS ALLOYS

La présente invention concerne des céphalosporines de formule générale dans laquelle - R1 est H our CH3, R2 est CH3, ou R1 et R2 forment un groupe 1,3 propylène, - R3 est alkyl, alkényl, alkynyl inférieur ou CH2COOalkyl, - R4 est H ou OH, le S étant lié au noyau pyridine en 2 ou 4, - A est H ou cation ou ester ou hémiacétal facilement hydrolysable, - et X un dérivé d'un acide minéral ou organique, L'invention concerne également - un procédé de préparation de ces nouvelles céphalosporines - et les médicaments qui contiennent lesdites céphalosporines. The present invention relates to cephalosporins of general formula: in which: R1 is H or CH3, R2 is CH3, or R1 and R2 taken together form a 1,3-propylene group, R3 is lower alkyl, alkenyl, alkynyl or CH2COO alkyl, R4 is H or OH, the S being bonded to the pyridine ring in 2 or 4 position, A is H or cation or ester or hemiacetal which is easily hydrolyzable, and X is a derivative of a mineral or organic acid. The invention also relates to a process for preparing these new cephalosporins and to the drugs containing said cephalosporins.