Cephalosporin derivatives substituted in position 3 with a thiomethylheterocyclic group, process for their preparation and pharmaceutical compositions containing them

• Main Authors: SALHI, ALI, LABEEUW, BERNARD
• Format: Patent
• Language: English; French; German
• Published: 08.06.1983
• Subjects: BLASTING; CHEMISTRY; FURNACES; FURNACES, KILNS, OVENS, OR RETORTS IN GENERAL; HEATING; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; KILNS; LIGHTING; MECHANICAL ENGINEERING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; OPEN SINTERING OR LIKE APPARATUS; ORGANIC CHEMISTRY; OVENS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; RETORTS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; WEAPONS

La présente invention concerne de nouvelles céphalosporines de formule générale dans laquelle R1=R2=CH3 ou bien R1 et R2 ensemble forment un groupe 1-3 propylène, A est H, un cation, un ester ou un hémiacétal, et R3 est un hétérocycle comportant cinq ou six atomes parmi lesquels au moins un atome d'azote; elle concerne également un procédé de préparation de ces céphalosporines et les médicaments en contenant. The present invention relates to new cephalosporins of general formula (II) in which R1=R2=CH3 or R1 and R2 together form a 1,3-propylene group, A is H, a cation, an ester or a hemiacetal, and R3 is a heterocycle comprising five or six atoms including at least one atom in the ring of nitrogen. It also relates to a process for preparing these cephalosporins and to the drugs containing them.