Pharmaceutical amides, and preparation, formulations and use thereof

Compounds of the general formula wherein X is a group R O and X is a group R O, or one of X and X is a group R and the other is hydroxy, wherein, R , R , R and R are the same or different and each represent hydrogen or a C1-4 alkyl group; Ph is a phenyl group, optionally substituted by one or more g...

Full description

Saved in:
Bibliographic Details
Main Authors HARDY, GEORGE WILLIAM, WILKINSON, SAMUEL
Format Patent
LanguageEnglish
French
German
Published 06.04.1983
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:Compounds of the general formula wherein X is a group R O and X is a group R O, or one of X and X is a group R and the other is hydroxy, wherein, R , R , R and R are the same or different and each represent hydrogen or a C1-4 alkyl group; Ph is a phenyl group, optionally substituted by one or more groups independently selected from halo nitro; and Y is a group of formula or a group of formula or a group of formula -NH-CH2-CO-; and basic salts thereof. These compounds have an advantageous enkephalinase inhibitory activity which renders the compounds useful in medical therapy, eg. to prolong and/or potentiate in a mammal, the effects of endogenous or exogenous enkephalins. The latter includes synthetic enkephalin analogues.
Bibliography:Application Number: EP19820108859