Meetod kinoloonkarboksüülhapete ja naftüridiinkarboksüülhapete saamiseks vabade aluste kujul
The present invention provides a method of making quinolone carboxylic acids or naphthyridine carboxylic acids in free base form, the method comprising dissolving a quinolone carboxylic acid salt or naphthyridine carboxylic acid salt in a solvent system to form a solution; combining the solution con...
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Main Authors | , , |
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Format | Patent |
Language | Estonian |
Published |
15.10.2001
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides a method of making quinolone carboxylic acids or naphthyridine carboxylic acids in free base form, the method comprising dissolving a quinolone carboxylic acid salt or naphthyridine carboxylic acid salt in a solvent system to form a solution; combining the solution containing the quinolone carboxylic acid salt or naphthyridine carboxylic acid salt with a calcium salt in an amount in the range of about 0.01% to about 5.0% by weight of the quinolone carboxylic acid salt or naphthyridine carboxylic acid salt and a base, the combination resulting in the formation of a precipitate; and collecting the precipitate. Also provided is a solid bulk pharmaceutical chemical composition which is the product resulting from the precipitation. |
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Bibliography: | Application Number: EE19970000290 |