COMPUESTOS DE PIRAZOLO[1,5-A]PIRIDINA SUSTITUIDOS COMO INHIBIDORES DE LA QUINASA RET

• Main Authors: BRANDHUBER, Barbara J, ANDREWS, Steven W, ARONOW, Sean, COOK, Adam, MORENO, David A, BLAKE, James F, KOLAKOWSKI, Gabrielle R, COLLIER, James, RAMANN, Ginelle A, REN, Li, HAAS, Julia, JIANG, Yutong, MCKENNEY, Megan L, WALLS, Shane M, METCALF, Andrew T, TANG, Tony P, MCNULTY, Oren T, MCFADDIN, Elizabeth A
• Format: Patent
• Language: Spanish
• Published: 31.07.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Se proporciona en la presente compuestos de la Fórmula I o sales o solvatos aceptables desde el punto de vista farmacéutico de estos, en donde A, B, X1, X2, X3, X4, Anillo D, E, Ra, Rb, n y m tienen los significados dados en la memoria descriptiva, que son inhibidores de quinasa RET y son útiles en el tratamiento y prevención de enfermedades que se pueden tratara con un inhibidor de quinasa RET, lo que incluye enfermedades y trastornos. Provided herein are compounds of the Formula I:or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.