DERIVADOS DE DIHIDRO-BENZO-OXAZINA Y DIHIDRO-PIRIDO-OXAZINA

• Main Authors: Yessin, Julie L, HÖGENAUER, Klemens, MOEBITZ, Henrik, ZECRI, Frédéric, LEWIS, Ian, HURTH, Konstanze, KAMMERTOENS, Karen, CHAMOIN, Sylvie, SOLDERMANN, Nicolas, SMITH, Alexander Baxter, WOLF, Romain, CARAVATTI, Giorgio, KALIS, Christoph
• Format: Patent
• Language: Spanish
• Published: 31.10.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

La invención se refiere a la preparación y uso de nuevos derivados de dihidro-benzo-oxazina y dihidro-pirido-oxazina como fármacos candidatos en forma libre o en forma de sal farmacéuticamente aceptable con valiosas propiedades de tipo fármaco, tales como, por ejemplo, una forma con estabilidad metabólica y farmacocinética adecuada, para la modulación, notoriamente la inhibición de la actividad o función de la familia de cinasa de fosfoinositida-3'-OH (posteriormente en la presente PI3K). The invention relates to dihydro-benzo-oxazine and dihydro-pyrido-oxazine compounds of the formula (I) and/or pharmaceutically acceptable salts and/or solvates thereof, wherein Y, V, W, U, Q, R1, R5, R7 and R30 are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.