DERIVADOS DE 8-CARBAMOIL-2-(2,3- PIRID- 6- ILO DI SUSTITUIDO) -1,2,3,4 -TETRAHIDROISOQUINOLINA COMO AGENTES INDUCTORES DE LA APOPTOSIS PARA EL TRATAMIENTO DEL CANCER Y ENFERMEDADES INMUNES Y AUTOINMUNES

Compuestos que inhiben la actividad de las proteínas antiapoptóticas Bcl-xL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades en las que se expresan las proteínas antiapoptóticas Bcl-xL. Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptot...

Full description

Saved in:
Bibliographic Details
Main Authors CHICAGO MUSIC, INC, Mylan Laboratories Limited, Fairbanks Morse, LLC, SANGSIN BRAKE CO, LTD, SABMILLER LIMITED, SOCIEDAD ANONIMA VICHY CATALAN, KUNZER, Aaron R, THE NATURE'S BOUNTY CO, LUCAS OIL PRODUCTS, INC, ANDERSEN TAX LLC, Reynolds Presto Products Inc, ADVANCED BIONUTRITION CORP, José Carlos Ruiz Cuenca
Format Patent
LanguageSpanish
Published 30.11.2015
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Compuestos que inhiben la actividad de las proteínas antiapoptóticas Bcl-xL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades en las que se expresan las proteínas antiapoptóticas Bcl-xL. Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y1 is phenylene or heteroarylene; L1 is a linker; Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc.
AbstractList Compuestos que inhiben la actividad de las proteínas antiapoptóticas Bcl-xL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades en las que se expresan las proteínas antiapoptóticas Bcl-xL. Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y1 is phenylene or heteroarylene; L1 is a linker; Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc.
Author Mylan Laboratories Limited
CHICAGO MUSIC, INC
Reynolds Presto Products Inc
SANGSIN BRAKE CO, LTD
THE NATURE'S BOUNTY CO
ANDERSEN TAX LLC
KUNZER, Aaron R
SOCIEDAD ANONIMA VICHY CATALAN
Fairbanks Morse, LLC
José Carlos Ruiz Cuenca
LUCAS OIL PRODUCTS, INC
ADVANCED BIONUTRITION CORP
SABMILLER LIMITED
Author_xml – fullname: CHICAGO MUSIC, INC
– fullname: Mylan Laboratories Limited
– fullname: Fairbanks Morse, LLC
– fullname: SANGSIN BRAKE CO, LTD
– fullname: SABMILLER LIMITED
– fullname: SOCIEDAD ANONIMA VICHY CATALAN
– fullname: KUNZER, Aaron R
– fullname: THE NATURE'S BOUNTY CO
– fullname: LUCAS OIL PRODUCTS, INC
– fullname: ANDERSEN TAX LLC
– fullname: Reynolds Presto Products Inc
– fullname: ADVANCED BIONUTRITION CORP
– fullname: José Carlos Ruiz Cuenca
BookMark eNqNjctKA0EQRWehCx_5h8KVwjRMMvGxLbsrpqC7q-2HkFUI0q5kEohf6VfZhHyAq8OFwz3X3cW0n-pV92so8gcaSWAIXpTG-IpO2KqFul_0o4LAkY2CJwVsBQxDKilzLmzkAdS8b1K_BJUpR1yzicJJ3gt7sewRtDgBfCOfKQF7U3SWSKeYRcAgIUviBAEjAlloJxkdN7-12tboNUXYAPkVRUcGzenIFd-4ASxZzuu2u_zafR_r7Myb7m5FWa9VPey39XjYfdap_mxJpzBfDsMwPj7j-C_pD2IoUOc
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID ECSP14000357A
GroupedDBID EVB
ID FETCH-epo_espacenet_ECSP14000357A3
IEDL.DBID EVB
IngestDate Fri Jul 19 14:54:38 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language Spanish
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_ECSP14000357A3
Notes Application Number: EC2020PI1400357
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151130&DB=EPODOC&CC=EC&NR=SP14000357A
ParticipantIDs epo_espacenet_ECSP14000357A
PublicationCentury 2000
PublicationDate 20151130
PublicationDateYYYYMMDD 2015-11-30
PublicationDate_xml – month: 11
  year: 2015
  text: 20151130
  day: 30
PublicationDecade 2010
PublicationYear 2015
RelatedCompanies POTISEK, Stephanie L
RelatedCompanies_xml – name: POTISEK, Stephanie L
Score 2.8745172
Snippet Compuestos que inhiben la actividad de las proteínas antiapoptóticas Bcl-xL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title DERIVADOS DE 8-CARBAMOIL-2-(2,3- PIRID- 6- ILO DI SUSTITUIDO) -1,2,3,4 -TETRAHIDROISOQUINOLINA COMO AGENTES INDUCTORES DE LA APOPTOSIS PARA EL TRATAMIENTO DEL CANCER Y ENFERMEDADES INMUNES Y AUTOINMUNES
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151130&DB=EPODOC&locale=&CC=EC&NR=SP14000357A
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bS8MwFA46RX3TqahTOYgMhQWn67ruYUiWZC7SNrVNRZ9k3SKIMMVN_I_-Kk_rvDztKVdOIB8nyZfLF0KOPTtyM7eFtATBpY6XNWl74A5pAxcnbWsHXj0r1D5Dt58613fNuwXy_PMWptAJ_SjEEdGjhujv02K8fv3bxBLF3crJWfaEWS-XPdMR1Rk7xukLx-Sq6HZkpIXmVc47klfDuJNEyCTyY7MWWyRLue5WLrQvb7v5s5TX_3NKb50sR2huPN0gC3ZSJqv85-u1MlkJZifeGJ0532STfAokXbdM6ASEBI9yFndZoJVPL-jJRa1BIVKxEhRcCsrXIBQkaWKUSZXQp0DPa1ip5gA10sSsr0SsVaJvUhVqX4UMuA40sCsZGpmACkXKjUZ88sZ8BizSkdGJSiBiMQPpAxoxLFBYH9vCNM__uYnhHmTYk3EgBYKcGwrSEMN7QFfQs9QWOepJw_sUO-XhF4IHyf91YGOblMYvY7tDILNt5JP1oTdothwHYR-5jfooe7T23GkN7HCXVOYY2ptbWiFrOaLfOov7pDR9e7cHuAKYZocFcl86aKTd
link.rule.ids 230,308,780,885,25564,76547
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT-MwELagrIAbj13xZoRQtSvVotA0SQ8Vcm2XGpI4mzgITlXTGgkhtYgW8R_5VUxCeZw4JU6sGWk-jT2fHzOEHPt25Oauh7QEwaWOnzdpa-AOaQODk5a1A7-el9k-I7eXOZc3zZsF8vBxF6bME_pSJkdEjxqiv8_K8frxaxFLlGcrpyf5PX6anHdNW1Tn7BinLxyTq6LTlrEWmlc5b0tejZJ2GiOTKLbNPLZIlryi5G4RO113imspj9_nlO4a-RWjuPFsnSzY6QZZ4R-l1zbIcjjf8cbXufNNN8mrQNJ1zYROQUjwKWdJh4VaBfSM_j2rNSjEKlGCgktBBRqEgjRLjTKZEvof0NMadqo5QI00CespkWiV6v-ZinSgIgZchxrYhYyMTEFFIuNGIz6FsoABi3VsdKpSiFnCQAaAQgwLFfZHXdjmRZ2bBG5BRl2ZhFIgyIWgMIvweQvoCnre-k2OutLwHkWj9D8h6Ev-zYCNP6QynoztFoHctpBP1of-oOk5DsI-chv1UX5n7anjDexwm-z-IGjnx7-HZKVnwqCPJrjaJasFuu85F_dIZfb0bPcxGpjlByWKbyLWp84
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=DERIVADOS+DE+8-CARBAMOIL-2-%282%2C3-+PIRID-+6-+ILO+DI+SUSTITUIDO%29+-1%2C2%2C3%2C4+-TETRAHIDROISOQUINOLINA+COMO+AGENTES+INDUCTORES+DE+LA+APOPTOSIS+PARA+EL+TRATAMIENTO+DEL+CANCER+Y+ENFERMEDADES+INMUNES+Y+AUTOINMUNES&rft.inventor=CHICAGO+MUSIC%2C+INC&rft.inventor=Mylan+Laboratories+Limited&rft.inventor=Fairbanks+Morse%2C+LLC&rft.inventor=SANGSIN+BRAKE+CO%2C+LTD&rft.inventor=SABMILLER+LIMITED&rft.inventor=SOCIEDAD+ANONIMA+VICHY+CATALAN&rft.inventor=KUNZER%2C+Aaron+R&rft.inventor=THE+NATURE%27S+BOUNTY+CO&rft.inventor=LUCAS+OIL+PRODUCTS%2C+INC&rft.inventor=ANDERSEN+TAX+LLC&rft.inventor=Reynolds+Presto+Products+Inc&rft.inventor=ADVANCED+BIONUTRITION+CORP&rft.inventor=Jos%C3%A9+Carlos+Ruiz+Cuenca&rft.date=2015-11-30&rft.externalDBID=A&rft.externalDocID=ECSP14000357A