DERIVADOS DE 8-CARBAMOIL-2-(2,3- PIRID- 6- ILO DI SUSTITUIDO) -1,2,3,4 -TETRAHIDROISOQUINOLINA COMO AGENTES INDUCTORES DE LA APOPTOSIS PARA EL TRATAMIENTO DEL CANCER Y ENFERMEDADES INMUNES Y AUTOINMUNES

Compuestos que inhiben la actividad de las proteínas antiapoptóticas Bcl-xL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades en las que se expresan las proteínas antiapoptóticas Bcl-xL. Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptot...

Full description

Saved in:
Bibliographic Details
Main Authors CHICAGO MUSIC, INC, Mylan Laboratories Limited, Fairbanks Morse, LLC, SANGSIN BRAKE CO, LTD, SABMILLER LIMITED, SOCIEDAD ANONIMA VICHY CATALAN, KUNZER, Aaron R, THE NATURE'S BOUNTY CO, LUCAS OIL PRODUCTS, INC, ANDERSEN TAX LLC, Reynolds Presto Products Inc, ADVANCED BIONUTRITION CORP, José Carlos Ruiz Cuenca
Format Patent
LanguageSpanish
Published 30.11.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:Compuestos que inhiben la actividad de las proteínas antiapoptóticas Bcl-xL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades en las que se expresan las proteínas antiapoptóticas Bcl-xL. Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y1 is phenylene or heteroarylene; L1 is a linker; Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc.
Bibliography:Application Number: EC2020PI1400357