HYDROXYACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The invention relates to compounds of formula (I), wherein R1, R2, R3, R4, R5, R8, R11, R14, A and n are as defined herein, that have valuable pro-apoptotic properties making it possible to use them in pathologies involving a defect in apoptosis, such as, for example, in the treatment of cancer, of...

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Main Authors CHANRION, Maia, PROSZENYAK, Agnes, MURRAY, James Brooke, SZLAVIK, Zoltan, GENESTE, Olivier, SIPOS, Szabolcs, KOTSCHY, Andras, DAVIDSON, James Edward, Paul, PACZAL, Attila, BALINT, Balazs
Format Patent
LanguageEnglish
Russian
Published 17.11.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to compounds of formula (I), wherein R1, R2, R3, R4, R5, R8, R11, R14, A and n are as defined herein, that have valuable pro-apoptotic properties making it possible to use them in pathologies involving a defect in apoptosis, such as, for example, in the treatment of cancer, of auto-immune and immunologic diseases, and to a method of preparation thereof and to pharmaceutical compositions comprising the same. Изобретение относится к соединениям формулы (I), где значения R1, R2, R3, R4, R5, R8, R11, R14, A и n определены далее, которые обладают ценными проапоптотическими свойствами, что позволяет использовать их при патологиях, в которые вовлечен дефект апоптоза, например для лечения злокачественных новообразований, аутоиммунных заболеваний и заболеваний иммунной системы, а также к способу их получения и к фармацевтическим композициям, содержащим их.
Bibliography:Application Number: EA20180090124