METHODS AND COMPOSITIONS FOR REDUCING IMMUNOSUPRESSION BY TUMOR CELLS

• Main Authors: SHAFFER, Donald, WUCHERPFENNIG, Kai W, ALVAREZ ARIAS, Diana, CANTOR, Harvey I, HACOHEN, Nir, DRANOFF, Glenn, ZHOU, Penghui
• Format: Patent
• Language: English; Russian
• Published: 23.06.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The present invention provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or chimeric antigen receptors (CAR)), and methods of use thereof. Изобретение отчасти относится к способам обнаружения мишеней для иммунотерапии in vivo, к терапевтическим композициям (например, мшРНК, иммунореактивные клетки, экспрессирующие мшРНК и/или химерные рецепторы антигенов (CAR)) и к способам их применения.