POLYCYCLIC AMIDE DERIVATIVES AS CDK9 INHIBITORS

Provided is a series of novel pyridine or pyrimidine derivatives of Formula (I)wherein A, Rand Rare as defined in the claims, which inhibit cyclin-dependent protein kinase 9 (CDK9) and may be useful for the treatment of CDK9-mediated diseases which are acute myeloid leukemia and breast cancer. Преду...

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Main Authors LAMB, Michelle, HAWKINS, Janet, VASBINDER, Melissa Marie, HIRD, Alexander, DE SAVI, Christopher, PIKE, Kurt Gordon, BARLAAM, Bernard Christophe
Format Patent
LanguageEnglish
Russian
Published 04.06.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided is a series of novel pyridine or pyrimidine derivatives of Formula (I)wherein A, Rand Rare as defined in the claims, which inhibit cyclin-dependent protein kinase 9 (CDK9) and may be useful for the treatment of CDK9-mediated diseases which are acute myeloid leukemia and breast cancer. Предусматривается ряд новых пиридиновых или пиримидиновых производных формулы (I)где A, Rи Rявляются такими, как определено в формуле изобретения, которые ингибируют циклинзависимую протеинкиназу 9 (CDK9) и могут быть пригодны для лечения заболеваний, опосредованных CDK9, представляющих собой острый миелоидный лейкоз и рак молочной железы.
Bibliography:Application Number: EA20180090094