MODIFIED SERPINS FOR THE TREATMENT OF BLEEDING DISORDERS

This invention relates to pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as...

Full description

Saved in:
Bibliographic Details
Main Authors POLDERDIJK, Stephanie, HUNTINGTON, James Andrew, BAGLIN, Trevor
Format Patent
LanguageEnglish
Russian
Published 23.12.2019
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Online AccessGet full text

Cover

More Information
Summary:This invention relates to pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro-coagulants for the treatment of bleeding. Изобретение относится к молекулам-прокоагулянтам серпина, сконструированным посредством модификации остатков P4, P2, P1 и/или P1' петли реактивного центра (RCL) для получения повышенной специфичности к протеазам-антикоагулянтам. Данные молекулы модифицированного серпина могут быть полезны в терапии, например, в качестве прокоагулянтов для лечения кровотечения.
Bibliography:Application Number: EA20160091235