INDUSTRIAL PROCESS FOR THE SYNTHESIS OF IVABRADINE SALTS

Process for the synthesis of ivabradine salts of formula (I)the chemical name of which is 3-{3-[((S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-ylmethyl)methyl-amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepine-2-one salts (HQ=HCl, HBr, HI, HNO3, HClO, (COOH)), and new intermediate...

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Main Authors MATRAVOELGYI Bela, UJVARI Viktor, NEMET Zoltan, KASSAI Ferencne, TEMESVARI Krisztina, FAIGL Ferenc, FARAGO Janos, KISS-BARTOS Dorottya, SZOKE Katalin, BODI Jozsef, KISS Robert
Format Patent
LanguageEnglish
Russian
Published 30.01.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Process for the synthesis of ivabradine salts of formula (I)the chemical name of which is 3-{3-[((S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-ylmethyl)methyl-amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepine-2-one salts (HQ=HCl, HBr, HI, HNO3, HClO, (COOH)), and new intermediates thereof. Certain crystalline forms of the acid addition salts of ivabradine (I) with nitric acid (I, HQ=HNO), hydrobromic acid (I, HQ=HBr), hydroiodic acid (I, HQ=HI), oxalic acid (I, HQ=(COOH)) and perchloric acid (I, HQ=HClO)). В изобретении представлен способ синтеза солей ивабрадина формулы (I)химическое название которых соли 3-{3-[((S)-3,4-диметокси-бицикло[4.2.0]окта-1,3,5-триен-7-илметил)-метиламино]пропил}-7,8-диметокси-1,3,4,5-тетрагидро-2Н-3-бензазепин-2-она (HQ=HCl, HBr, HI, HNO, HClO, (СООН)), и новых промежуточных продуктов. Некоторые кристаллические формы кислотно-аддитивных солей ивабрадина (I) с азотной кислотой (I, HQ=HNO), бромисто-водородной кислотой (I, HQ=HBr), иодисто-водородной кислотой (I, HQ=HI), щавелевой кислотой (I, HQ=(СООН)) и перхлорной кислотой (I, HQ=HClO)).
Bibliography:Application Number: EA20120001525