PROCESS FOR THE PREPARATION OF TRANS 4-AMINO-CYCLOHEXYL ACETIC ACID ETHYL ESTER HCl

• Main Authors: JUHASZ BALINT, HEGEDUS LASZLO, MATHE TIBOR, BENCE, MARKOS DENES, CZIBULA LASZLO, NAGYNE BAGDY JUDIT
• Format: Patent
• Language: English; Russian
• Published: 30.10.2014
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a process for the preparation of trans 4-amino-cyclohexil ethyl acetate HCl wherein: a) 4-nitrophenyl acetic acid is hydrogenated in a protic solvent at a temperature between 40-50°C in the presence of Pd/C under 0.1-0.6 bar overpressure, and b) 4-aminophenyl acetic acid obt...