SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS

• Main Authors: BULLION ANN-MARIE, REDMAN ANIKO, CAMPBELL ANN-MARIE, ROWLEY, R. BRUCE, SCOTT WILLIAM, MICHELS MARTIN, WOOD JILL, HENTEMANN MARTIN
• Format: Patent
• Language: English; Russian
• Published: 29.11.2013
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds of formulapharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients. Изобретение касается новых соединений 2,3-дигидроимидазо[1,2-с]хиназолина формулыфармацевтических композиций, содержащих такие соединения, применения этих соединений или композиций для ингибирования фосфотидилинозитол-3-киназы (PI3K) и лечения болезней, связанных с активностью фосфотидилинозитол-3-киназы (PI3K), при определенном лечении гиперпролиферативных нарушений и/или нарушений ангиогенеза, в качестве отдельного агента или в комбинации с другими активными компонентами.