COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS

The invention provides novel pyrimidine derivatives of formula (I)and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic...

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Main Authors MICHELLYS PIERRE-YVES, NGUYEN TRUC, NGOC, PEI WEI, JIANG TAO, GE YONGHUI, MARSILJE THOMAS, H, GAO ZHAOBO, WU BAOGEN, LI YUNCHENG, ZHU XUEFENG, HUANG CHEN, CHEN BEI
Format Patent
LanguageEnglish
Russian
Published 28.06.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides novel pyrimidine derivatives of formula (I)and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, c-ros oncogene (ROS), insulin-like growth factor (IGF-1R), and/or insulin receptor (InsR) or a combination thereof. Изобретение относится к новым производным пиримидина формулы (1)и их фармацевтическим композициям, а также к способам применения таких соединений. Например, производные пиримидина по изобретению могут использоваться для лечения, облегчения или профилактики состояния, которое связано с ингибированием активности анапластической лимфомной киназы (ALK), онкогена c-ros (ROS), инсулиноподобного фактора роста (IGF-1R) и/или инсулинового рецептора (InsR) или их комбинации.
Bibliography:Application Number: EA20100001597