CRYSTALLINE FORMS OF DIMETHOXY DOCETAXEL AND METHODS FOR PREPARING SAME

The invention relates to anhydrides, solvates and ethanol heterosolvates and hydrates of dimethoxy docetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate of 4-α-acetoxy-2α-benzoyloxy-5 ,20-epoxy-1- -hydroxy-7 ,10 -dimethoxy-9-oxo-tax-11-ene-13α-yle, and to the preparation there...

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Main Authors ZASKE LIONEL, DUFRAIGNE MARIELLE, RORTAIS PATRICIA, GUILIANI ALEXANDRE, BILLOT PASCAL, MANGIN FABRICE, ELMALEH HAGIT
Format Patent
LanguageEnglish
Russian
Published 28.02.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to anhydrides, solvates and ethanol heterosolvates and hydrates of dimethoxy docetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate of 4-α-acetoxy-2α-benzoyloxy-5 ,20-epoxy-1- -hydroxy-7 ,10 -dimethoxy-9-oxo-tax-11-ene-13α-yle, and to the preparation thereof. Изобретение относится к безводным формам, сольватам и этанольным гетеросольватам, гидратам диметоксидоцетаксела или (2R,3S)-3-трет-бутоксикарбониламино-2-гидрокси-3-фенилпропионат 4-α-ацетокси-2α-бензоилокси-5β,20-эпокси-1-β-гидрокси-7β,10β-диметокси-9-оксо-такс-11-ен-13α-ила и их получению.
Bibliography:Application Number: EA20100070856